Theophylline drug interactions pdf

Effect of cimetidine on pharmacokinetics of theophylline in healthy. An interaction is known to occur when the effects of one drug are changed by. Theophylline has mild interactions with at least 26 different drugs. Theophylline oral interactions with other medication. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Theophylline fda prescribing information, side effects. How dangerous are the drugdrug interactions of theophylline with caffeine and ciprofloxacin. Whatever the mechanism, the interaction may be sufficient to necessitate adjustment of the theophylline dosage, preferably. Concerning drug interactions with theophylline journal of. Pdf theophylline and antiparasitic drug interactions. This document does not contain all possible interactions. Pdf theophylline dimethyxanthine has been used to treat airway diseases for over 80 years. It works in the airways by relaxing muscles, opening breathing passages.

Theophylline concentrations are increased by cimetidine, however, famotidine, nizatidine, and ranitidine do not appear to interact. Theophylline interactions bnf content published by nice. Find patient medical information for theophylline oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Subjects in the theophylline interaction study were administered single 200mg aminophylline tablets aminophylline tablets, containing 158 mg of theophylline. Theophylline interactions learning article pharmaceutical journal. Pdf to determine a change in theophylline pharmacokinetics during concomitant thiabendazole or mebendazole therapy, we studied six normal, healthy. Pharmacokinetic drug interactions with theophylline. She has been using salbutamol and fluticasonesalmeterol. Even if a slight kinetic interaction between caffeine and theophylline does exist, its clinical importance is probably limited because most patients do not abruptly. Drug interactions fall into three broad categories. A moderate drug interaction exists between cimetidine and theophylline. Commonlyused drugs that interact with theophylline. Theophylline appears to antagonise the sedative and anxiolytic effects of benzodiazepines.

Nsaids undergo hepatic metabolism, so the clinical interaction may be the result of combined pharmacokinetic and pharmacodynamic. Drug interactions should be considered in the differential diagnosis of theophylline toxicity. Advair diskus fluticasone salmeterol aminophylline. When given orally, it is well absorbed, with peak effects in 2 hours. Since up to 90% of a theophylline dose is biotransformed, drugs influencing microsomal enzyme systems in the liver may affect the elimination of theophylline. View interaction reports for theophylline and the medicines listed below. See what others have said about theophylline, including the effectiveness, ease of use and side effects. Theophylline toxicity due to drug interaction sciencedirect. Theophylline interacts with a wide variety of drugs. Theophylline drug interactions can alter the level of theophylline in your blood or make some drugs less effective, among other things. Overview of drug interactions with the quinolones oxford academic. View detailed information regarding this drug interaction. Josep ibrrent, inaki izquierdo, ricardo cabezas, and francese jane.

It must be used regularly to prevent wheezing and shortness of breath. Both smoking and excessive caffeine consumption can alter the blood levels of theophylline, which may affect the dosing. Application of a physiologically based pharmacokinetic model to. The drug is metabolized in the liver and excreted in the urine. Theophylline oral tablet is only available as a generic drug. Theophylline is given systemically orally as slowrelease preparations for chronic treatment and intravenously for acute exacerbations of asthma. Theophylline is used to treat the symptoms of asthma or other lung conditions that block your airways, such as emphysema or chronic. Theophylline is used to treat lung diseases such as asthma and copd bronchitis, emphysema.